Description
Guaifenesin 10% Topical Cream made with Lipoderm™ base with
test proven penetration ability. We have found this to be very effective to
treat trigger point pain and/or muscle tightness. Many times stress headaches
are caused by muscle tension in the neck muscles and may be relieved by using
topical guaifenesin cream.
Studies and MOA:
Nitric oxide (NO) mediates activation of satellite precursor
cells to enter the cell cycle. This provides new precursor cells for skeletal
muscle growth and muscle repair from injury or disease. Targeting a new drug
that specifically delivers NO to muscle has the potential to promote normal
function and treat neuromuscular disease, and would also help to avoid side
effects of NO from other treatment modalities. In this research, we examined
the effectiveness of the NO donor, iosorbide dinitrate (ISDN), and a muscle
relaxant, methocarbamol, in promoting satellite cell activation assayed by
muscle cell DNA synthesis in normal adult mice. The work led to the development
of guaifenesin dinitrate (GDN) as a new NO donor for delivering nitric oxide to
muscle. The results revealed that there was a strong increase in muscle
satellite cell activation and proliferation, demonstrated by a significant 38%
rise in DNA synthesis after a single transdermal treatment with the new
compound for 24 h. Western blot and immunohistochemistry analyses showed that
the markers of satellite cell myogenesis, expression of myf5, myogenin, and
follistatin, were increased after 24 h oral administration of the compound in
adult mice. This research extends our understanding of the outcomes of NO-based
treatments aimed at promoting muscle regeneration in normal tissue. The
potential use of such treatment for conditions such as muscle atrophy in disuse
and aging, and for the promotion of muscle tissue repair as required after
injury or in neuromuscular diseases such as muscular dystrophy, is highlighted.
GuqiWang†,
Frank J.Burczynski‡,
Brian B.Hasinoff‡,
KaidongZhang§,
QilongLu†
and Judy E.Anderson*§
A lesser publicized and thus lesser known fact among
fibromyalgia sufferers is that guaifenesin has a skeletal muscle
relaxant property, and a form of guaifenesin known as guafenesin carbomate is
used for this purpose. This may explain some of the symptomatic relief
experienced by fibromyalgia sufferers who take guaifenesin.
Nitric oxide (NO) mediates activation of satellite precursor
cells to enter the cell cycle. This provides new precursor cells for skeletal
muscle growth and muscle repair from injury or disease. Targeting a new drug
that specifically delivers NO to muscle has the potential to promote normal
function and treat neuromuscular disease, and would also help to avoid side
effects of NO from other treatment modalities. In this research, we examined
the effectiveness of the NO donor, iosorbide dinitrate (ISDN), and a muscle
relaxant, methocarbamol, in promoting satellite cell activation assayed by
muscle cell DNA synthesis in normal adult mice. The work led to the development
of guaifenesin dinitrate (GDN) as a new NO donor for delivering nitric oxide to
muscle. The results revealed that there was a strong increase in muscle
satellite cell activation and proliferation, demonstrated by a significant 38%
rise in DNA synthesis after a single transdermal treatment with the new
compound for 24 h. Western blot and immunohistochemistry analyses showed that
the markers of satellite cell myogenesis, expression of myf5, myogenin, and
follistatin, were increased after 24 h oral administration of the compound in
adult mice. This research extends our understanding of the outcomes of NO-based
treatments aimed at promoting muscle regeneration in normal tissue. The
potential use of such treatment for conditions such as muscle atrophy in disuse
and aging, and for the promotion of muscle tissue repair as required after
injury or in neuromuscular diseases such as muscular dystrophy, is highlighted.
GuqiWang†,
Frank J.Burczynski‡,
Brian B.Hasinoff‡,
KaidongZhang§,
QilongLu†
and Judy E.Anderson*§
A lesser publicized and thus lesser known fact among
fibromyalgia sufferers is that guaifenesin has a skeletal muscle
relaxant property, and a form of guaifenesin known as guafenesin carbomate is
used for this purpose. This may explain some of the symptomatic relief
experienced by fibromyalgia sufferers who take guaifenesin.
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