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  Guaifenesin Cr 10gm
topical muscle relaxant


 
Our Price: $9.98

Availability:: Usually Ships in 24 Hours
Product Code: GUAIF CRM

Description
 
Description

Guaifenesin 10% Topical Cream made with Lipoderm™ base with test proven penetration ability. We have found this to be very effective to treat trigger point pain and/or muscle tightness. Many times stress headaches are caused by muscle tension in the neck muscles and may be relieved by using topical guaifenesin cream.

Studies and MOA:

Nitric oxide (NO) mediates activation of satellite precursor cells to enter the cell cycle. This provides new precursor cells for skeletal muscle growth and muscle repair from injury or disease. Targeting a new drug that specifically delivers NO to muscle has the potential to promote normal function and treat neuromuscular disease, and would also help to avoid side effects of NO from other treatment modalities. In this research, we examined the effectiveness of the NO donor, iosorbide dinitrate (ISDN), and a muscle relaxant, methocarbamol, in promoting satellite cell activation assayed by muscle cell DNA synthesis in normal adult mice. The work led to the development of guaifenesin dinitrate (GDN) as a new NO donor for delivering nitric oxide to muscle. The results revealed that there was a strong increase in muscle satellite cell activation and proliferation, demonstrated by a significant 38% rise in DNA synthesis after a single transdermal treatment with the new compound for 24 h. Western blot and immunohistochemistry analyses showed that the markers of satellite cell myogenesis, expression of myf5, myogenin, and follistatin, were increased after 24 h oral administration of the compound in adult mice. This research extends our understanding of the outcomes of NO-based treatments aimed at promoting muscle regeneration in normal tissue. The potential use of such treatment for conditions such as muscle atrophy in disuse and aging, and for the promotion of muscle tissue repair as required after injury or in neuromuscular diseases such as muscular dystrophy, is highlighted.

GuqiWang, Frank J.Burczynski, Brian B.Hasinoff, KaidongZhang§, QilongLu and Judy E.Anderson*§

A lesser publicized and thus lesser known fact among fibromyalgia sufferers is that guaifenesin has a skeletal muscle relaxant property, and a form of guaifenesin known as guafenesin carbomate is used for this purpose. This may explain some of the symptomatic relief experienced by fibromyalgia sufferers who take guaifenesin.

Nitric oxide (NO) mediates activation of satellite precursor cells to enter the cell cycle. This provides new precursor cells for skeletal muscle growth and muscle repair from injury or disease. Targeting a new drug that specifically delivers NO to muscle has the potential to promote normal function and treat neuromuscular disease, and would also help to avoid side effects of NO from other treatment modalities. In this research, we examined the effectiveness of the NO donor, iosorbide dinitrate (ISDN), and a muscle relaxant, methocarbamol, in promoting satellite cell activation assayed by muscle cell DNA synthesis in normal adult mice. The work led to the development of guaifenesin dinitrate (GDN) as a new NO donor for delivering nitric oxide to muscle. The results revealed that there was a strong increase in muscle satellite cell activation and proliferation, demonstrated by a significant 38% rise in DNA synthesis after a single transdermal treatment with the new compound for 24 h. Western blot and immunohistochemistry analyses showed that the markers of satellite cell myogenesis, expression of myf5, myogenin, and follistatin, were increased after 24 h oral administration of the compound in adult mice. This research extends our understanding of the outcomes of NO-based treatments aimed at promoting muscle regeneration in normal tissue. The potential use of such treatment for conditions such as muscle atrophy in disuse and aging, and for the promotion of muscle tissue repair as required after injury or in neuromuscular diseases such as muscular dystrophy, is highlighted.

GuqiWang, Frank J.Burczynski, Brian B.Hasinoff, KaidongZhang§, QilongLu and Judy E.Anderson*§

A lesser publicized and thus lesser known fact among fibromyalgia sufferers is that guaifenesin has a skeletal muscle relaxant property, and a form of guaifenesin known as guafenesin carbomate is used for this purpose. This may explain some of the symptomatic relief experienced by fibromyalgia sufferers who take guaifenesin.



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